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May 26, 2008 Update #74N |
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WILL GREEN TEA EGCG PROTECT AGAINST ALZHEIMER'S DISEASE?
Background
Alzheimer's disease is characterized by the development of beta-amyloid
plaques, neurofibrillary tangles, that replace the neuron pathways of the brain needed for
memory. Theoretically, a reduction in beta-amyloid plaque levels would curb the progress
of and memory loss associated with Alzheimer's disease.
Note: Tau is a biochemical marker used to determine the level of
neurofibrillary degeneration associated with Alzheimer's disease progression. The
Alzheimer transgenic (tg) mouse is a popular animal model used in studying Alzheimer's
disease.
Featured Research Study
Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice.
Brain Res. 2008 Apr 7. Rezai-Zadeh K, et.al.
Click Here for PubMed Abstract of Study
Study Highlights
This research team previously reported a reduction in beta-amyloid
levels and plaques in mice subsequent to i.p EGCG injection. Here, EGCG was
administered to Alzheimer tg mice both orally and by i.p. injection. The study concluded
"that EGCG provided cognitive benefit to Tg mice with both i.p. and oral administration..."
and that EGCG dietary supplementation is a "potentially safe and effective" prophylactic
agent for Alzheimer's disease.
Comments
This study, although performed in mice, holds promise for all concerned
about Alzheimer's disease.
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Dr. Paul's Tea & Health Update, WWW.DRPAULSUPDATES.ORG, supports tea and health educational programs by bringing recent research studies into public awareness.
Copyright © 2008 Dr. Paul's School of Tea and Health, LLC. All rights reserved.
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