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9-08-2008

Dr. Paul's Tea & Health Update

#89c

WILL EGCG OF GREEN TEA HELP INHIBIT BREAST CANCER CELL GROWTH?
   The expression of p27Kip1 is receiving increased research interest as a target gene related to breast cancer. Instability of p27Kip1 is associated with increased breast cancer growth activity. Ideally, any agent that stabilizes p27Kip1 activity will be protective against many common estrogen-sensitive forms of breast cancer.

Epigallocatechin gallate (EGCG) stabilizes p27kip1 in estrogen- stimulated MCF-7 cells through downregulation of the Skp2 protein.
Endocrinology. 2008 Aug 21. Huang HC, et.al.
Click Here for PubMed Abstract of Study

   This study examined the possible mechanism whereby EGCG may inhibit the growth of estrogen-stimulated breast cancer cells (MCF-7) in the laboratory. It found that EGCG stabilizes p27kip1 in estrogen- stimulated MCF-7 cells through downregulation of the Skp2 protein. The study concludes that:

   "therapeutic strategies designed to reduce Skp2 may...play an important clinical role in treatment of breast cancer cells."

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