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| 8-25-2008 |
Dr. Paul's Tea & Health Update |
#87a |
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WILL ECg OF GREEN TEA REDUCE ATHEROSCLEROSIS-RELATED FOAM CELL FORMATION?
Foam cell formation in the artery wall lining is a frequent, early step leading to atherosclerotic plaque
formation which, in turn, leads to cardiovascular disease.
Note: ECg [(-)-Epicatechin gallate], like EGCG, is a major component of green but not black tea.
Note: Foam cells are lipid-laden (cholesterol-laden) macrophage-related cells that accumulate in the inner lining of the
artery wall as part of the progression toward cardiovascular diseases such as heart attack and stroke.
(-)-Epicatechin gallate accumulates in foamy macrophages in human atherosclerotic aorta: Implication in the anti-atherosclerotic actions of tea catechins.
Biochem Biophys Res Commun. 2008 Jul 25. Kawai Y, et.al.
Click Here for PubMed Abstract of Study
The investigators found that:
"ECg could suppress the gene expression of a scavenger receptor CD36, a key molecule for foam cell formation, in macrophage cells."
The results suggest that one way green tea may reduce one's risk of cardiovascular disease is that ECg may reduce macrophage-foam cell-related activity in the artery walls.
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Dr. Paul's Tea & Health Update, WWW.DRPAULSUPDATES.ORG, supports tea and
health educational programs by bringing recent research studies into public
awareness. - Copyright © 2008 Dr. Paul's School of Tea and Health, LLC.
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